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  • Lay Summary - A pilot study examining the molecular determinants of postnatal airway smooth muscle growth - Project Description The thickness of the airway smooth muscle (ASM) layer is increased in asthma and likely contributes to symptoms such as breathlessness. Emerging data supports the premise that the thickened ASM layer may have a development origin. Airway development begins early in gestation, in which the smooth muscle lining the upper airways first appears and then develops sequentially to smaller airways. The volume of the airway smooth muscle (ASM) layer increases thereafter until adulthood, however, the molecular mechanisms producing this growth are not well described. Using a sheen model of airway development, the objective of this study is to determine the molecular mechanisms for growth of the ASM layer. This study will reveal molecular targets governing airway growth for early intervention and prevention to asthma.

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